Tag · 12 articles

biogerontology

Articles tagged biogerontology, drawn from 5 portals. Tags are assigned by hand and cut across the portal structure, so this set will not match any single subject area.

Longevity12 Foundations4 People4 Organizations2 Genetics1

Articles: 12
Portals spanned: 5
Words: 17k
Co-occurring tags: 43

12 of 12 shown

Aubrey de GreyPeopleBritish biogerontologist who proposed the SENS damage-repair framework for rejuvenation and popularized the idea of longevity escape velocity.presentContested
Buck Institute for Research on AgingOrganizationsAn independent research institute in Novato, California, opened in 1999 as the first in the world dedicated solely to the biology of aging.presentEstablished
Cynthia KenyonPeopleAmerican molecular geneticist whose 1993 finding that a single daf-2 mutation doubles the lifespan of C. elegans made aging a tractable genetic problem.presentEstablished
David SinclairPeopleAustralian-American biologist at Harvard known for sirtuin and NAD+ research, the information theory of aging, and disputes over the strength of his public claims.presentContested
Geroscience hypothesisLongevityThe proposition that aging is the shared upstream driver of most chronic disease, so that slowing it would delay many conditions at once rather than one at a time.2030sEmerging
Hallmarks of agingLongevityThe consensus taxonomy of cellular and molecular processes held to drive mammalian aging, set out as nine mechanisms in 2013 and expanded to twelve in 2023.presentEstablished
Interventions Testing ProgramOrganizationsA National Institute on Aging programme that tests whether candidate anti-aging compounds extend lifespan in genetically heterogeneous mice, run in parallel at three sites.presentEstablished
Leonard HayflickPeopleAmerican microbiologist who showed in 1961 that normal human cells divide a finite number of times in culture, and who argued for fifty years afterwards that aging is not a disease.historicalHistorical
Longevity escape velocityLongevityThe hypothetical threshold at which medicine adds remaining life expectancy faster than time subtracts it, making death by aging recede indefinitely.2050s+Speculative
Naked mole-ratLongevityA small eusocial African rodent whose flat mortality curve, tumour resistance and anoxia tolerance make it comparative biogerontology's central model organism.presentEstablished
Negligible senescenceLongevityThe condition of organisms whose mortality rate and physiological function show no measurable decline with age after reaching maturity.presentEstablished
ProgeriaLongevityA rare fatal childhood disorder caused by one recurrent LMNA mutation, and the standing test case for whether a genetic disease can accelerate aging itself.presentEstablished