https://futurehumanwiki.com Latest reviewed entries on longevity, genetics, biotech, pharma, cybernetics, and human enhancement. en-us https://futurehumanwiki.com/articles/in-vivo-gene-editing https://futurehumanwiki.com/articles/in-vivo-gene-editing Genetic Modification Mon, 22 Jun 2026 12:00:00 GMT Editing genes inside the body has moved from concept to approved therapy, and delivery — not the editor — is now the dominant constraint on what can be treated. (Evidence: Clinical practice; Risk: Moderate) https://futurehumanwiki.com/articles/mtor-rapamycin https://futurehumanwiki.com/articles/mtor-rapamycin Longevity Science Sat, 20 Jun 2026 12:00:00 GMT Rapamycin extends lifespan in multiple animal models by inhibiting mTOR, making it the most reproducible pharmacological longevity signal — and a live question for human healthspan trials. (Evidence: Early human; Risk: Moderate) https://futurehumanwiki.com/articles/hallmarks-of-aging https://futurehumanwiki.com/articles/hallmarks-of-aging Longevity Science Thu, 18 Jun 2026 12:00:00 GMT A shared framework that organizes aging into interconnected biological processes, giving longevity research a common map of what to measure and target. (Evidence: Early human; Risk: Unknown) https://futurehumanwiki.com/articles/germline-editing https://futurehumanwiki.com/articles/germline-editing Genetic Modification Mon, 15 Jun 2026 12:00:00 GMT Editing embryos, eggs, or sperm would make genetic changes heritable. The technical barriers are serious and the ethical and governance barriers are, for now, decisive. (Evidence: Speculative; Risk: High) https://futurehumanwiki.com/articles/biohacking-risk-ledger https://futurehumanwiki.com/articles/biohacking-risk-ledger Biohacking & Risk Sun, 14 Jun 2026 12:00:00 GMT Self-experimentation should be judged by reversibility, measurement quality, downside planning, and evidence strength. (Evidence: Clinical practice; Risk: Low) https://futurehumanwiki.com/articles/embryo-polygenic-screening https://futurehumanwiki.com/articles/embryo-polygenic-screening Reproduction & Development Sun, 14 Jun 2026 12:00:00 GMT Screening IVF embryos for common-disease risk scores is commercially available, but the predicted benefits are small, uncertain, and ethically contested. (Evidence: Early human; Risk: Moderate) https://futurehumanwiki.com/articles/cellular-reprogramming https://futurehumanwiki.com/articles/cellular-reprogramming Longevity Science Fri, 12 Jun 2026 12:00:00 GMT Partial reprogramming aims to restore youthful cell function without erasing identity or triggering uncontrolled growth. (Evidence: Preclinical; Risk: High) https://futurehumanwiki.com/articles/brain-computer-interfaces https://futurehumanwiki.com/articles/brain-computer-interfaces Cybernetics Thu, 11 Jun 2026 12:00:00 GMT BCIs connect neural activity to computers, prosthetics, and communication systems, with medical restoration leading enhancement. (Evidence: Early human; Risk: High) https://futurehumanwiki.com/articles/xenotransplantation https://futurehumanwiki.com/articles/xenotransplantation Frontier Biotech Wed, 10 Jun 2026 12:00:00 GMT Gene-edited pig organs have kept human recipients alive for weeks to months, opening a possible route around the chronic shortage of human donor organs. (Evidence: Early human; Risk: High) https://futurehumanwiki.com/articles/personalized-rna-medicine https://futurehumanwiki.com/articles/personalized-rna-medicine Future Pharma Mon, 08 Jun 2026 12:00:00 GMT Programmable RNA platforms can compress the path from molecular insight to tailored therapy, especially for rare or rapidly changing targets. (Evidence: Clinical practice; Risk: Moderate) https://futurehumanwiki.com/articles/epigenetic-clocks https://futurehumanwiki.com/articles/epigenetic-clocks Genetic Modification Fri, 05 Jun 2026 12:00:00 GMT DNA methylation clocks estimate biological age and may become trial tools, but they are not a substitute for health outcomes. (Evidence: Early human; Risk: Low) https://futurehumanwiki.com/articles/cell-therapies https://futurehumanwiki.com/articles/cell-therapies Future Pharma Fri, 05 Jun 2026 12:00:00 GMT Living cells engineered to fight disease have transformed some blood cancers and are being pushed toward solid tumors, autoimmunity, and off-the-shelf manufacturing. (Evidence: Clinical practice; Risk: High) https://futurehumanwiki.com/articles/longevity-pharma-pipeline https://futurehumanwiki.com/articles/longevity-pharma-pipeline Future Pharma Wed, 03 Jun 2026 12:00:00 GMT Aging-targeted pharma is moving from supplement claims toward indication-led trials, combination logic, and prevention endpoints. (Evidence: Early human; Risk: Moderate) https://futurehumanwiki.com/articles/wearable-sensors https://futurehumanwiki.com/articles/wearable-sensors Cybernetics Tue, 02 Jun 2026 12:00:00 GMT Continuous sensing turns the body into a data stream. The value depends on whether measurements are accurate, actionable, and paired with a decision — not on the data alone. (Evidence: Clinical practice; Risk: Low) https://futurehumanwiki.com/articles/gene-editing-platforms https://futurehumanwiki.com/articles/gene-editing-platforms Genetic Modification Mon, 01 Jun 2026 12:00:00 GMT CRISPR, base editing, prime editing, and epigenetic editing expand what medicine can rewrite, regulate, or silence. (Evidence: Clinical practice; Risk: High) https://futurehumanwiki.com/articles/neurostimulation https://futurehumanwiki.com/articles/neurostimulation Mind & Cognition Mon, 01 Jun 2026 12:00:00 GMT Stimulating the brain with implanted or external devices is established therapy for some conditions — and a contested tool for enhancement. (Evidence: Clinical practice; Risk: Moderate) https://futurehumanwiki.com/articles/targeted-protein-degradation https://futurehumanwiki.com/articles/targeted-protein-degradation Future Pharma Sat, 30 May 2026 12:00:00 GMT Instead of blocking a protein, degraders instruct the cell to destroy it — expanding the range of disease targets beyond what traditional inhibitors can reach. (Evidence: Early human; Risk: Moderate) https://futurehumanwiki.com/articles/nad-metabolism https://futurehumanwiki.com/articles/nad-metabolism Longevity Science Thu, 28 May 2026 12:00:00 GMT NAD+ declines with age and is central to energy metabolism and repair, but whether raising it with precursors produces meaningful healthspan benefit in humans remains unsettled. (Evidence: Early human; Risk: Low) https://futurehumanwiki.com/articles/cybernetic-prosthetics https://futurehumanwiki.com/articles/cybernetic-prosthetics Cybernetics Mon, 25 May 2026 12:00:00 GMT Next-generation prosthetics combine robotics, neural control, sensory feedback, and adaptive software. (Evidence: Early human; Risk: Moderate) https://futurehumanwiki.com/articles/in-vitro-gametogenesis https://futurehumanwiki.com/articles/in-vitro-gametogenesis Reproduction & Development Sun, 24 May 2026 12:00:00 GMT Making eggs and sperm from ordinary cells would upend reproduction — it has produced healthy pups in mice, but a safe human version does not yet exist. (Evidence: Preclinical; Risk: High) https://futurehumanwiki.com/articles/senolytics https://futurehumanwiki.com/articles/senolytics Longevity Science Wed, 20 May 2026 12:00:00 GMT Drugs that remove or quiet senescent cells could reduce inflammatory aging signals, but benefits depend heavily on context. (Evidence: Early human; Risk: Moderate) https://futurehumanwiki.com/articles/sensory-implants https://futurehumanwiki.com/articles/sensory-implants Cybernetics Wed, 20 May 2026 12:00:00 GMT Sensory implants are the most mature human-machine interfaces: cochlear implants restore useful hearing at scale, while retinal prostheses show how hard vision remains. (Evidence: Clinical practice; Risk: Moderate) https://futurehumanwiki.com/articles/psychedelic-therapy https://futurehumanwiki.com/articles/psychedelic-therapy Mind & Cognition Tue, 19 May 2026 12:00:00 GMT Psilocybin and MDMA paired with therapy show promise for depression and PTSD in trials, but regulatory approval, durability, and trial design remain unsettled. (Evidence: Early human; Risk: Moderate) https://futurehumanwiki.com/articles/cognitive-enhancement https://futurehumanwiki.com/articles/cognitive-enhancement Mind & Cognition Sat, 16 May 2026 12:00:00 GMT Attempts to boost focus, memory, or mood with drugs, supplements, and stimulation are common, but robust enhancement in healthy people is weaker than the marketing suggests. (Evidence: Early human; Risk: Moderate) https://futurehumanwiki.com/articles/regenerative-organ-platforms https://futurehumanwiki.com/articles/regenerative-organ-platforms Frontier Biotech Sun, 10 May 2026 12:00:00 GMT Organoids, bioprinting, xenotransplantation, and perfusion systems are converging on the bottleneck of organ replacement. (Evidence: Early human; Risk: High) https://futurehumanwiki.com/articles/heterochronic-exchange https://futurehumanwiki.com/articles/heterochronic-exchange Longevity Science Sun, 10 May 2026 12:00:00 GMT Sharing a young circulatory environment rejuvenates some tissues in animals, but the human versions — young plasma or plasma dilution — remain unproven and easy to oversell. (Evidence: Preclinical; Risk: Moderate) https://futurehumanwiki.com/articles/mitochondrial-replacement https://futurehumanwiki.com/articles/mitochondrial-replacement Reproduction & Development Wed, 06 May 2026 12:00:00 GMT Swapping faulty mitochondria to prevent inherited mitochondrial disease has produced babies under strict regulation — a narrow, heritable germline intervention. (Evidence: Early human; Risk: Moderate) https://futurehumanwiki.com/articles/synthetic-biology https://futurehumanwiki.com/articles/synthetic-biology Frontier Biotech Tue, 28 Apr 2026 12:00:00 GMT Engineered cells and biological circuits could sense disease, manufacture therapies, and adapt inside the body. (Evidence: Early human; Risk: Moderate) https://futurehumanwiki.com/articles/memory-modulation https://futurehumanwiki.com/articles/memory-modulation Mind & Cognition Tue, 28 Apr 2026 12:00:00 GMT Techniques to weaken, strengthen, or even implant memories work in animals and hint at trauma treatments, but human memory engineering is early and ethically fraught. (Evidence: Preclinical; Risk: High) https://futurehumanwiki.com/articles/synthetic-wombs https://futurehumanwiki.com/articles/synthetic-wombs Reproduction & Development Wed, 22 Apr 2026 12:00:00 GMT Extracorporeal support systems have kept premature lambs developing for weeks, pointing toward partial ectogenesis for extreme prematurity — a long way from full gestation. (Evidence: Preclinical; Risk: High)