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categories: ["longevity"]categories: ["longevity"]tags: ["cellular senescence", "aging", "sasp", "clinical trials", "drug repurposing", "apoptosis"]tags: ["cellular senescence", "aging", "sasp", "clinical trials", "drug repurposing", "apoptosis"]summary: "Drugs that selectively kill senescent cells, an approach that reduces age-related pathology in mice but has so far produced modest or null results in humans."summary: "Drugs that selectively kill senescent cells, an approach that reduces age-related pathology in mice but has so far produced modest or null results in humans."updated: "2026-07-27"updated: "2026-08-23"humanEvidence: "Human data are small open-label pilots of nine to fourteen patients, one showing reduced senescent-cell markers in fat and skin, plus two randomized failures; every lifespan result is from mice."humanEvidence: "Human data are small open-label pilots of nine to fourteen patients, one showing reduced senescent-cell markers in fat and skin, plus two randomized failures; every lifespan result is from mice."access: "No senolytic is approved for any aging indication; dasatinib is an approved cancer drug available only on prescription, and fisetin and quercetin are sold over the counter as supplements at doses taken from mouse studies."access: "No senolytic is approved for any aging indication; dasatinib is an approved cancer drug available only on prescription, and fisetin and quercetin are sold over the counter as supplements at doses taken from mouse studies."reversibility: "partly-reversible"reversibility: "partly-reversible"lines 59–64 → 59–6844 unchanged lines not shown
resulting populations are not biochemically uniform. [[cellular-senescence]] treats the cell stateresulting populations are not biochemically uniform. [[cellular-senescence]] treats the cell stateitself, including its triggers, markers, and useful roles; this article treats the drugs. Senescenceitself, including its triggers, markers, and useful roles; this article treats the drugs. Senescenceappears in its own right as one of the [[hallmarks-of-aging]].appears in its own right as one of the [[hallmarks-of-aging]]. ```figure{"key": "senescent-mefs-sabg", "caption": "The target, in mouse cells: late-passage fibroblasts grow large and flat and stain for SA-β-galactosidase, the standard senescence marker. The stain identifies the cells senolytics aim to kill; it does not harm them."}``` Resistance to apoptosis is the drugging opportunity. Senescent cells depend on what the field callsResistance to apoptosis is the drugging opportunity. Senescent cells depend on what the field callssenescent cell anti-apoptotic pathways: members of the BCL-2 family, PI3K–AKT signalling, p53–p21senescent cell anti-apoptotic pathways: members of the BCL-2 family, PI3K–AKT signalling, p53–p21removed, struck through added, underlinedLine numbers count the serialised markdown of each revision, frontmatter included.
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