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categories: ["enhancement", "longevity"]categories: ["enhancement", "longevity"]tags: ["cognition", "supplements", "magnesium", "memory", "sleep", "dementia"]tags: ["cognition", "supplements", "magnesium", "memory", "sleep", "dementia"]summary: "A magnesium salt of a vitamin C breakdown product, sold as Magtein, that raised brain magnesium and memory in rats and has small, industry-funded human trials."summary: "A magnesium salt of a vitamin C breakdown product, sold as Magtein, that raised brain magnesium and memory in rats and has small, industry-funded human trials."updated: "2026-10-27"updated: "2026-10-29"humanEvidence: "Four small placebo-controlled trials, one of a multi-ingredient formula and each funded by a company selling the ingredient, report modest gains on cognitive or sleep measures over 3 to 12 weeks; brain uptake is shown only in rats."humanEvidence: "Four small placebo-controlled trials, one of a multi-ingredient formula and each funded by a company selling the ingredient, report modest gains on cognitive or sleep measures over 3 to 12 weeks; brain uptake is shown only in rats."access: "Sold without prescription as a dietary supplement in the United States and authorised in the EU as a novel food ingredient in 2024; the ingredient is patented and licensed under the Magtein brand."access: "Sold without prescription as a dietary supplement in the United States and authorised in the EU as a novel food ingredient in 2024; the ingredient is patented and licensed under the Magtein brand."reversibility: "reversible"reversibility: "reversible"lines 20–26 → 20–265 unchanged lines not shown
"rows": [ "rows": [ { "label": "Also called", "value": "MgT, L-TAMS, Magtein" }, { "label": "Also called", "value": "MgT, L-TAMS, Magtein" }, { "label": "Composition", "value": "Two L-threonate anions per magnesium ion" }, { "label": "Composition", "value": "Two L-threonate anions per magnesium ion" }, { "label": "Magnesium content", "value": "About 7.5–8.8% by weight" }, { "label": "Magnesium content", "value": "About 7.5-8.8% by weight" }, { "label": "Developed by", "value": "Guosong Liu and colleagues" }, { "label": "Developed by", "value": "Guosong Liu and colleagues" }, { "label": "First reported", "value": "2010, in rats" }, { "label": "First reported", "value": "2010, in rats" }, { "label": "Patent holder", "value": "Neurocentria (Magceutics)" }, { "label": "Patent holder", "value": "Neurocentria (Magceutics)" },lines 36–42 → 36–429 unchanged lines not shown
```keyfacts```keyfacts[[ { "value": "145 mg", "label": "Elemental magnesium in a 2 g daily dose", "note": "the dose in the largest trial; the rest of the weight is threonate" }, { "value": "145 mg", "label": "Elemental magnesium in a 2 g daily dose", "note": "the dose in the largest trial; the rest of the weight is threonate" }, { "value": "100", "label": "Participants in the largest trial of MgT alone", "note": "adults aged 18–45, six weeks" }, { "value": "100", "label": "Participants in the largest trial of MgT alone", "note": "adults aged 18-45, six weeks" }, { "value": "2010", "label": "First report of the compound", "note": "in young and aged rats" } { "value": "2010", "label": "First report of the compound", "note": "in young and aged rats" }]]``````lines 93–99 → 93–9950 unchanged lines not shown
## Outlook## Outlook The questions are straightforward and unanswered as of October 2026: whether oral MgT raises magnesium in the human brain, whether its cognitive effect survives a trial its makers do not fund, and whether it does anything for older adults that matters outside a test battery. Trial registries list further studies with universities as lead sponsors, including in collegiate athletes, a group for whom the anti-doping rules described in [[enhancement-in-sport]] make supplement purity a practical concern. Until those report, MgT shares the position of [[nad-precursors]]: a plausible mechanism in animals, a consumer market, and human data too thin to separate a real effect from noise. Its newer trials borrow their sleep outcomes from the [[wearable-health-sensors]] popular in [[biohacking]] and [[quantified-self]] circles, which makes them cheap to run and hard to compare with clinical sleep research. No trial has examined [[healthspan]] or any outcome the [[geroscience-hypothesis]] treats as central, and "cognitive age" joins the other [[aging-biomarkers|unvalidated age estimates]] used to market interventions. For cognition in later life, [[exercise-and-aging|exercise]] and [[sleep-and-longevity|adequate sleep]] have far more support. Whether MgT belongs in discussions of [[human-enhancement]] or [[intelligence-amplification]] at all depends on a replication that has not yet been published.Three plain questions remain unanswered as of October 2026: whether oral MgT raises magnesium in the human brain, whether its cognitive effect survives a trial its makers do not fund, and whether it does anything for older adults that matters outside a test battery. Trial registries list further studies with universities as lead sponsors, including in collegiate athletes, a group for whom the anti-doping rules described in [[enhancement-in-sport]] make supplement purity a practical concern. Until those report, MgT shares the position of [[nad-precursors]]: a plausible mechanism in animals, a consumer market, and human data too thin to separate a real effect from noise. Its newer trials borrow their sleep outcomes from the [[wearable-health-sensors]] popular in [[biohacking]] and [[quantified-self]] circles, which makes them cheap to run and hard to compare with clinical sleep research. No trial has examined [[healthspan]] or any outcome the [[geroscience-hypothesis]] treats as central, and "cognitive age" joins the other [[aging-biomarkers|unvalidated age estimates]] used to market interventions. For cognition in later life, [[exercise-and-aging|exercise]] and [[sleep-and-longevity|adequate sleep]] have far more support. Whether MgT belongs in discussions of [[human-enhancement]] or [[intelligence-amplification]] at all depends on a replication that has not yet been published. ## See also## See also removed, struck through added, underlinedLine numbers count the serialised markdown of each revision, frontmatter included.
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