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categories: ["genetics", "nanomedicine"]categories: ["genetics", "nanomedicine"]tags: ["delivery", "mrna", "gene therapy", "crispr", "nanomedicine", "vaccines"]tags: ["delivery", "mrna", "gene therapy", "crispr", "nanomedicine", "vaccines"]summary: "Four-component lipid vesicles that carry mRNA and other nucleic acids into cells, the delivery system behind mRNA vaccines and the first systemic in vivo CRISPR therapies."summary: "Four-component lipid vesicles that carry mRNA and other nucleic acids into cells, the delivery system behind mRNA vaccines and the first systemic in vivo CRISPR therapies."updated: "2026-10-29"updated: "2026-11-01"humanEvidence: "Billions of mRNA vaccine doses and an approved siRNA drug establish that the carrier works and is tolerated in people, and a phase 1 trial showed a single infusion of an LNP-delivered CRISPR editor cut circulating transthyretin."humanEvidence: "Billions of mRNA vaccine doses and an approved siRNA drug establish that the carrier works and is tolerated in people, and a phase 1 trial showed a single infusion of an LNP-delivered CRISPR editor cut circulating transthyretin."access: "Approved LNP products are in clinical use (mRNA vaccines at population scale, patisiran as an infused drug for a rare disease), while the genome-editing therapies using the same carrier are trial-only."access: "Approved LNP products are in clinical use (mRNA vaccines at population scale, patisiran as an infused drug for a rare disease), while the genome-editing therapies using the same carrier are trial-only."reversibility: "context"reversibility: "context"lines 96–101 → 96–10281 unchanged lines not shown
- [[targeted-drug-delivery]]- [[targeted-drug-delivery]]- [[dna-nanotechnology]]- [[dna-nanotechnology]]- [[germline-editing]]- [[germline-editing]]- [[in-vivo-car-t]] ## References## References removed, struck through added, underlinedLine numbers count the serialised markdown of each revision, frontmatter included.
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