Portals / Longevity
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Senolytics and Senomorphics
Drugs that remove or quiet senescent cells could reduce inflammatory aging signals, but benefits depend heavily on context.
Hallmarks of Aging
A shared framework that organizes aging into interconnected biological processes, giving longevity research a common map of what to measure and target.
mTOR Inhibition and Rapamycin
Rapamycin extends lifespan in multiple animal models by inhibiting mTOR, making it the most reproducible pharmacological longevity signal — and a live question for human healthspan trials.
NAD+ Metabolism and Boosters
NAD+ declines with age and is central to energy metabolism and repair, but whether raising it with precursors produces meaningful healthspan benefit in humans remains unsettled.
Cellular Reprogramming
Partial reprogramming aims to restore youthful cell function without erasing identity or triggering uncontrolled growth.
Heterochronic Exchange and Young Plasma
Sharing a young circulatory environment rejuvenates some tissues in animals, but the human versions — young plasma or plasma dilution — remain unproven and easy to oversell.